These include NCAM1 (also associated with neuroticism, anxiety, mood disorders and anorexia nervosa)23,25,40, CADM2 (also associated with neuroticism, anxiety and cannabis use)21,22, PHD finger protein 2 (PHF2)/family with sequence similarity 120A (FAM120A) (also associated with neuroticism, depression and autism)23,24 and dedicator of cytokinesis 9 (DOCK9). The gene discussed is DOCK9; the disease is major depressive disorder.