IGFBP5 and breast cancer: In their integrative eQTL-based analysis of 15 published breast cancer risk loci, Li et al. identified three cis-associations (2q35-IGFBP5, 5q11-SETD9 and 16q12-TOX3, Table 1) and three trans-associations, which they defined as associations with downstream genes for which there was evidence of regulation by a TF mapping locally to the GWAS locus [60] (6q25-ESR1, 9q31-KLF4 and 8q24-MYC).