For example, the 10q26 breast cancer risk locus was referred to as the FGFR2 locus before Meyer et al. carried out functional studies that implicated regulation of FGFR2 expression through allele-specific binding of E2F1 and FOXA1 as the likely mechanism by which this locus influences risk [21, 94]. This evidence concerns the gene FGFR2 and breast carcinoma.