EZH2 and acute myeloid leukemia: Third, inhibition of methyltransferases EZH1 and EZH2 by UNC1999 greatly induced miR-139 expression in MLL-AF9 AML patient samples and other subtypes of AML, demonstrating direct silencing of Mir139 by PRC2 in AML, which is in agreement with previous findings in solid cancers [44, 45].