In recognition of the ability of SARS-CoV-2 to induce an inflammatory response following infection of intestinal cells, we used Caco-2 cells to test the ability of spike protein RBD and heat-inactivated SARS-CoV-2 to activate NF-kappaB and induce secretion of IFN-γ and CXCL10. Here, IFNG is linked to infection.