In addition, functional and mechanistic studies suggest that STEAP3 participates in promoting HCC cell proliferation through modulating nuclear trafficking of EGFR and the activities of EGFR-RAC1-ERK-STAT3 and RAC1-JNK-STAT6 axes, which might be contributed, at least in part, to the progression of human HCC. Here, STAT3 is linked to hepatocellular carcinoma.