This report describes the evaluation of two I-SPY2 trial arms: a neoadjuvant non-chemotherapy regimen, T-DM1 + pertuzumab (T-DM1/P), and a dual-HER2 targeting regimen, paclitaxel + trastuzumab + pertuzumab (THP), compared to paclitaxel + trastuzumab alone (TH) for HER2+ breast cancer in the I-SPY2 trial. Here, ERBB2 is linked to breast carcinoma.