As expected, SNS-032 remarkably downregulated the levels of phospho-RNA Pol II (Ser 2), phospho-RNA Pol II (Ser 5), and phospho-RNA Pol II (Ser 7), but not the total RNA Pol II, CDK7, and CDK9 in tested cell line of ESCC (Fig. 1B). The gene discussed is CDK9; the disease is esophageal squamous cell carcinoma.