In addition, KYSE30 cells transfected with a plasmid encoding human Mcl-1 were resistant to SNS-032-induced apoptosis; in contrast, knockdown of Mcl-1 by lentiviral shRNAs potentiated the apoptosis of ESCC cells induced by SNS-032. The gene discussed is MCL1; the disease is esophageal squamous cell carcinoma.