To our knowledge, MTDH has been reported that its overexpression promoted PTX resistance, tamoxifen resistance, and doxorubicin resistance in luminal-A and TNBC breast cancer [30–32], and MTDH-based DNA vaccine suppressed lung metastasis and enhanced chemosensitivity to doxorubicin in breast cancer [33]. Here, MTDH is linked to breast cancer.