68Ga-FAPi-46 SUVmax and SUVmean, and the FAP immunohistochemistry score, were higher in cancer tissue than in tumor-adjacent non-cancer tissue: mean SUVmax was 7.7 (95% CI, 5.1–10.3) versus 1.6 (95% CI, 0.9–2.2; P < 0.001), respectively; mean SUVmean was 6.2 (95% CI, 4.0–8.3) versus 1.0 (95% CI, 0.7–1.3; P < 0.001), respectively; and mean FAP immunohistochemistry score was 2.8 (95% CI, 2.6–3.0; P < 0.001) versus 0.9 (95% CI, 0.4–1.4; P < 0.001), respectively (Fig. 3). Here, FAP is linked to cancer.