RNF111 also contains 3 small ubiquitin-like modifier interacting motifs in its N-terminal region which confer to RNF111 small ubiquitin-like modifier-targeted ubiquitin ligase function involved in promyelocytic leukemia degradation in response to arsenic treatment (10) and in xeroderma pigmentosum ubiquitylation during DNA damage repair induced by UV (11). The gene discussed is RNF111; the disease is acute promyelocytic leukemia.