RNF111 and xeroderma pigmentosum: RNF111 also contains 3 small ubiquitin-like modifier interacting motifs in its N-terminal region which confer to RNF111 small ubiquitin-like modifier-targeted ubiquitin ligase function involved in promyelocytic leukemia degradation in response to arsenic treatment (10) and in xeroderma pigmentosum ubiquitylation during DNA damage repair induced by UV (11).