Mutations in HSPB8 are associated with distal hereditary motor neuropathy, Charcot-Marie-Tooth disease Type 2L (CMT2L; OMIM: 608673), and more recently with Neuronopathy, Distal Hereditary Motor, Type IIa (HMN2A; OMIM: 158590) [206]. Here, HSPB8 is linked to Charcot-Marie-Tooth disease axonal type 2L.