Combined with our data showing that CASP6 does not impact the priming of the CASP11-NLRP3 inflammasome or the expression of IRGB10, a key molecule involved in releasing LPS from the bacteria (12) (Figs. 2 and S1), these data suggest that the function of CASP6 may occur after CASP11 senses and binds LPS during gram-negative bacterial infection. Here, CASP6 is linked to gram-negative bacterial infections.