If a patient has at least one risk factor (diabetes, hypertension, obesity, smoking) and concomitant HF, MI, CKD, or other CV/kidney disorder, oral antidiabetic drugs and/or subcutaneous insulin administration should be stopped immediately; intravenous insulin administration should be initiated, and treatment with ACE-i/ARBs and statins should be continued [153]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.