NPPB and type 2 diabetes mellitus: In the PONTIAC trial, high-risk people were T2D pre-selected based on NT-proBNP levels showing a beneficial effect in terms of primary prevention of hospitalization and death due to cardiac events [80], and the STOP-HF trial supports the finding that BNPs are a reliable screening tool in an at-risk population in reducing newly-diagnosed HF and the prevalence of LV dysfunction [81].