Several gene signatures related to cancer invasion, including invasiveness signature, epithelial-mesenchymal transition (EMT), pan-fibroblast TGFb response signature (Pan-F-TBRS) and two key immune cells in tumor microenvironment (effector CD8+ T and cancer associated fibroblasts (CAFs)) were chosen to further investigation of the role of LMRG score in tumorigenesis and metastasis [49, 50]. The gene discussed is CD8A; the disease is neoplasm.