NR1H4 and Obesity: In some cases, for example, tempol treatment in mice, decreased these bacteria and BSH activity in the intestine and increased T-β-MCA level, and then inhibited FXR activation, resulting in suppressing the synthesis of ceramide to prevent hepatic steatosis (Jiang et al. 2015), glucose intolerance and obesity (Gonzalez et al. 2016; Jiang et al. 2015; Turpin et al. 2014).