2018). However, Sal did not affect the mRNA levels of Hif-1α under normoxia. Taken together, these data suggest that Sal induces an increase in Hif-1α protein in microglia triggered neuroprotection under normoxia, which might be associated with the prevention of AMS in Rhodiola crenulata. Here, HIF1A is linked to ablepharon macrostomia syndrome.