HIF1A and ablepharon macrostomia syndrome: 2015), fatigue (Shevtsov et al. 2003) and Alzheimer’s disease (Wang et al. 2017). Several studies have indicated that Rhodiola crenulata prevents and treats AMS by regulating the hypoxia-inducible factor-1 (Hif-1) signalling pathway (Wang et al. 2019). Salidroside (Sal), rhodiosin, tyrosol and p-hydroxybenzyl alcohol, the major functional ingredients of Rhodiola crenulata, may form a material basis for its anti-hypoxic effects (Chang et al. 2007, 2018; Liang et al. 2018; Yan et al. 2018). However, the active compounds and the exact role of Rhodiola crenulata in AMS remain unclear.