RUNX2 and cleidocranial dysplasia 1: Commonly, the diagnosis of CCD is clinical, and hypoplastic clavicles, open fontanelles, and supernumerary teeth constitute a characteristic triad.1 In patients with atypical characteristics, molecular analysis can be used for differential diagnosis,7 as variable loss of function of Cbfa1 may give rise to a clinical variability ranging from isolated primary dental anomalies to classic CCD.8