Moreover, G0/G1 phase cells were enhanced, whereas S phase and G2/M phase cells were reduced, by depletion of LBH in the cells, although the overexpression of LBH showed a reversed effect (Fig. 3G), suggesting that LBH was able to inhibit cell cycle arrest at the G0/G1 phase in glioma cells. The gene discussed is LBH; the disease is central nervous system cancer.