INS and Insulin resistance: The Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) assay showed that blood glucose levels in HFD-fed Tet1+/- mice more readily respond to insulin injection than WT mice (Figure 1H), but not in Chow-fed mice (Figure 1—figure supplement 3B), suggesting a beneficial effect of Tet1 deficiency in the development of insulin resistance in HFD-fed mice.