Genes annotated to these top 10 CpGs have previously been implicated in brain-related phenotypes, including psychiatric disorders (MDD [65–68], schizophrenia [69]), neurodegenerative disorders (neurofibrillary tangles and PHF-tau measurement in Alzheimer’s Disease [70]), and cognitive traits (mathematical ability, self- reported educational attainment [71]). This evidence concerns the gene MAPT and major depressive disorder.