As ITGB3 gene encodes integrins β3 and form platelet glycoprotein (GP)IIb/IIIa which contributes in fibrinogen, and polycythemia vera characterized with thrombocytosis is one kind of cMPNs, we speculate that ITGB3 may play an important role in JAK2V617F-positive cMPNs and warrants subsequent in-depth study. Here, ITGB3 is linked to Thrombocytosis.