PTEN and myeloproliferative neoplasm: demonstrated that deletion of lncRNA X–inactive specific transcript in the blood compartment of mice led to the genome-wide changes followed by mixed MPN/MDS In BCR-ABL-mediated chronic myeloid leukemia (CML), lncRNA BGL3 binds microRNAs to inhibit phosphatase and tensin homolog (PTEN) expression, and silencing of tumor-suppressor lncRNA-BGL3 promotes BCR-ABL-mediated cellular transformation [9].