Correspondingly, PELI1 knockdown specifically promoted the expression of the Bcl‐XL protein in IR‐treated TE‐1, ECA‐109, SCC‐9 and SiHa squamous carcinoma cells (Fig. 6I, Fig. S5A), while overexpression of PELI1 also reduced the Bcl‐XL protein levels in these tumor cells (Fig. 6J, Fig. S5B). Here, BCL2L1 is linked to neoplasm.