In concert with the pattern of PELI1‐modulated noncanonical NF‐κB signaling, knockdown of PELI1, which enhanced IR‐induced noncanonical NF‐κB signaling, significantly promoted the transcription of the anti‐apoptotic gene Bclx1 in IR‐treated TE‐1 tumor cells (Fig. 6G). The gene discussed is PELI1; the disease is neoplasm.