Recently, the functional study of PELI1 in tumors has shown that the expression of PELI1 in lung adenocarcinoma is significantly higher than that of matched cancer‐adjacent normal tissues, and this contributes to lung tumorigenesis and promotes epithelial–mesenchymal transition by mediating the Lys63‐linked polyubiquitination of Snail and Slug [20]. This evidence concerns the gene SNAI2 and cancer.