SOST and coronary artery disorder: It is not possible to attribute causality given the largely cross‐sectional nature of our study, and it is equally plausible that our findings represent a causal effect of CAD severity on sclerostin levels, perhaps representing a physiological adaptation to vascular calcification.(49) Another possibility is that certain medications associated with CAD severity and/or risk factors have been found to be associated with BMD and might also be related to sclerostin levels and hence contribute to a possible causal effect of CAD on sclerostin levels.