Bovijn and colleagues selected two SOST single‐nucleotide polymorphisms (SNPs) on the basis of associations with BMD and sclerostin expression in human osteoblast cultures, which were found to be associated with an increased risk of CVD and related risk factors such as T2DM and hypertension.(52) Conversely, Holdsworth and colleagues selected variants in the SOST region based on associations with reduced SOST expression in arterial or heart tissue and increased BMD, which showed no association with CVD‐related outcomes in UK Biobank.(53). This evidence concerns the gene SOST and Hypertension.