DLG4 and Alzheimer disease: Analysis of sections immunolabeled for the postsynaptic scaffolding protein, PSD95, revealed a significant deficit in the number of postsynaptic puncta (Fig. 2A1a-1d, and B1) in 3xTg-AD mice treated with vehicle (Fig. 2A1b) compared to WT vehicle mice (Fig. 2A1a), which was restored by SPG302 treatment at both 3 and 30 mg/kg doses (Fig. 2A1c, 1d).