SYP and Alzheimer disease: However, SPG302 treatment (at 30 mg/kg) rescued deficits in the colocalization of PSD95- and synaptophysin-labeled elements (Fig. 2A3a-3d) in 3xTg-AD mice at 30 mg/kg mice (Fig. 2B3), considered an immunohistochemical measure of possible functional synapses.