Correlations between the loss of dendritic spine synapses and cognitive decline are supported by work in mouse models [20, 23–28], by studies of the spine actin regulatory proteins spinophilin [29, 30], cofilin [31], and drebrin [32], as well as 3D electron microscopy in postmortem AD brain [33, 34]. This evidence concerns the gene CFL1 and Alzheimer disease.