For example, expression levels of drebrin, a key postsynaptic ABP involved in the clustering and stabilization of F-actin in spines [47] and spine maturation, are reduced in the hippocampus and neocortex of AD patients, and in the superior temporal cortex of those with prodromal mild cognitive impairment, correlating with cognitive status [47–49]. This evidence concerns the gene DBN1 and Alzheimer disease.