Xu et al. reported that downregulation of OSBPL3 correlates with reduced survival of colon cancer patients with advanced nodal metastasis and grade 3 colon cancer (Xu et al., 2020), but another recent research showed the contrary result that upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression (Jiao et al., 2020). Here, HIF1A is linked to malignant colon neoplasm.