OSBPL3 and malignant colon neoplasm: Xu et al. reported that downregulation of OSBPL3 correlates with reduced survival of colon cancer patients with advanced nodal metastasis and grade 3 colon cancer (Xu et al., 2020), but another recent research showed the contrary result that upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression (Jiao et al., 2020).