In this work, a group of survival analyses by GEPIA2, OncoLnc tools, and Kaplan–Meier plotter indicated a strong prognostic relevance between high level of OSBPL3 expression and poor OS, DFS, PFI, and DFI prognosis for low-grade glioma; poor OS, DFS, and PFI for uveal melanoma; and poor PFI and DFI for prostate adenocarcinoma while better clinical prognosis for testicular germ cell tumor cases. The gene discussed is OSBPL3; the disease is central nervous system cancer.