The clinical pathological grade of a tumor cancer closely correlates with malignancy and differentiation, and we found a positive correlation between elevated expression levels of OSBPL3 and high-grade tumors in both the cancer biopsies (breast, lung, stomach, and colon cancers) (Figure 2A) and the tumor statistics data from the GEPIA2 database (COAD, LIHC, OV, PAAD, and TGCT) (Figure 1D). The gene discussed is OSBPL3; the disease is malignant colon neoplasm.