RNPC3 and amyotrophic lateral sclerosis: Importantly, RNP compartments and missense mutations in RBPs are thought to be central to the pathogenesis of several neuronal disorders such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), inclusion body myopathy (IBM) (Li et al., 2013; Ramaswami et al., 2013; Tsang et al., 2020).