In addition, the FGFR4 Arg388 allele has been linked to advanced stage and more frequent lymph node (LN) metastases than the wild-type homozygote (Gly/Gly) in the cohorts of CRC (12), BC (12, 34), PC (15), and LC (18). Here, FGFR4 is linked to laryngotracheoesophageal cleft.