Preclinical and clinical trials using α-GalCer have shown that this therapy is safe, exhibits durable activation, and increases the number of iNKT, NK, tumor-specific, CD4+, CD8+ T, and B cells (148, 149, 151, 153–156, 160, 161, 169, 172, 173, 175). This evidence concerns the gene CD4 and neoplasm.