SPHK2 and cancer: ABC294640 (opaganib, Yeliva, 3-(4-chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide) is a selective inhibitor of both SPHK2 and DES1 that decreases the synthesis of the pro-proliferative and antiapoptotic lipid S1P, which may eventually lead to the induction of apoptosis and inhibition of cell proliferation in cancer cells overexpressing SPHK2 (75–77, 82).