SPRR1B and melanoma: After exclusion (Supplementary Table 2), 17 cases of melanoma were positive for IGF2BP3 and had a high positive rate, and 8 cases in normal skin tissues (50%) were weakly positive for IGF2BP3 (Figure 11A).The difference between the positive rate of IGF2BP3 in melanoma and normal skin was seen(Figure 11B).7 cases of primary melanoma (87.5%) were positive for SPRR1B, and 2 cases in metastatic melanoma (25%) were very low weakly positive for SPRR1B (Figure 11C).The difference between the positive rate of SPRR1B in Primary melanoma and metastatic melanoma was seen in Figure 11D.