SPRR1B and metastatic malignant neoplasm: The network genes were mainly members of KRT family and SPRR family, and the most core genes in the network (Figure 8G) were IVL, LOR and SPRR1B.In addition, we found that the significantly down-regulated gene network in metastatic cancer was similar to the significantly down-regulated gene network in the IGF2BP3 overexpression group (Figure 2A), both of which included KRT family members and SPRR1B, etc.