In addition, in GSE15605 cancer in situ (Figure 9B), the correlation number between SPRR1B and IGF2BP3 expression was -0.42, p value was 0.004; as well as all cases including normal tissues and metastatic cancers (Figure 9C), the correlation coefficient between them is -0.45, and the p value is 6.12e-5, which is also consistent with the down-regulation of SPRR1B in IGF2BP3 high expression group. This evidence concerns the gene IGF2BP3 and metastatic malignant neoplasm.