On the one hand, Wnt signaling executes an adverse effect on antitumor immunity by suppressing the effect of T-cell differentiation, inhibiting expansion of CD8+ T cells, promoting M2-like polarization of TAM, etc. On the other hand, Wnt signaling promotes DC maturation and activation, and promoting the trafficking of DC and T cells to tumor tissue (32). This evidence concerns the gene CD8A and neoplasm.