Using targeted capture and deep sequencing analysis for germline and somatic loss-of-function mutations in 30 genes, including BRCA1, BRCA2, and 11 other genes in the HR pathway in 390 ovarian carcinomas, Pennington et al. documented that 26% of OCCC in their cohort harbored HR-related mutations (98). This evidence concerns the gene BRCA1 and ovarian carcinoma.