Furthermore, an increase of coagulation factors (D-dimers, von Willebrand Factor, thrombin, fibrin-/ogen, soluble P-selectin and prothrombin fragments 1 + 2) in genitourinary cancers has been associated with vascular thrombosis and tumor initiation, as well as metastatic progression by John et al. [14]; indeed the deposition of fibrin-/ogen and other adhesive glycoproteins in the cellular matrix together with the action of metalloproteinases [15] promotes adhesion, proliferation and migration both during angiogenesis and during tumor growth [16]. This evidence concerns the gene CD226 and urogenital neoplasm.