Prasugrel and ticagrelor, third-generation P2Y12 inhibitors, circumvent the clinical limitations of clopidogrel, such as liver metabolism, drug interactions, and polymorphisms in genes encoding platelet receptors, thereby exerting faster and stronger antiplatelet aggregation properties, which suggests their usefulness in patients with ACS and diabetes [8, 9]. This evidence concerns the gene P2RY12 and diabetes mellitus.