A role for IGSF10 in CCD has not been previously reported, though pathogenic IGSF10 mutations have been detected in self-limited delayed puberty (DP) and congenital hypogonadotropic hypogonadism (CHH) (Howard et al., 2016; Amato et al., 2019). The gene discussed is IGSF10; the disease is congenital hypogonadotropic hypogonadism.