Therefore, we speculated that the occurrence of IS1 immune subtype pancreatic cancer may be related to NK cell resting and NK cell activation, the occurrence of IS2 immune subtype pancreatic cancer may be related to Neutrophils and T cells CD4 memory activation, the occurrence of IS3 immune subtype pancreatic cancer may be related to T cells CD4 memory activation and T cells CD8 activation, while the occurrence of IS4 immune subtype pancreatic cancer may be related to protein kinase. This evidence concerns the gene CD4 and familial pancreatic carcinoma.