Combined with the results of consensus cluster analysis, we speculated that pancreatic cancer IS1 immune subtype and IS2 immune subtype may be associated with tumor necrosis factor and protein kinase, whose main function may be to regulate the development of pancreatic cancer cells; IS3 immune subtype had the highest expression of GS1 gene and GS3 gene, which may be a new immune subtype of pancreatic cancer; IS4 immune subtype had the lowest expression of GS1 gene, GS2 gene, and GS3 gene and the highest GS4 level, which may be a subtype related to protein kinase. Here, TNF is linked to familial pancreatic carcinoma.