AIM2 and infection: Diverse infections and immune challenges activate caspase-1 in cells through different inflammasomes, including NLRP3, NLRP1, apoptotic speck-like protein containing a caspase recruitment domain (ASC), NOD-like receptor family, caspase recruitment domain (CARD) containing 4 (NLRC4) and absent in melanoma 2 (AIM2) (71).