Furthermore, the ssRNA-Pim-3-shRNA dual-function therapy established by Liu’s group not only enhanced the activation and IFN-α secretion of pDCs, promoted the apoptosis and inhibited the proliferation of melanoma cells, but also enhanced the activation of CD8+ T cells and NK cells and simultaneously reduced the proportion of Tregs and myeloid-derived suppressor cells (MDSCs), and ultimately reversed the tumor immunosuppressive microenvironment (52). The gene discussed is CD8A; the disease is neoplasm.