Importantly, ALL-MSC did not exhibit transcriptional differences in the typical MSCs markers CD73, CD90, and CD105 (Supplementary Figure S6C), but a very low transcriptional expression of CAR-niche associated genes CXCL12 and SCF were found in CXCL10+CXCL11+ ALL-MSC3 (Supplementary Figure S6D). The gene discussed is NT5E; the disease is acute lymphoblastic leukemia.