CXCL10hiCXCL11hi zones may represent exclusive leukemia-positioning niches where B-ALL cells may also contribute to CXCL11 expression (Supplementary Figure S7B) presumably relevant for positioning of CXCR3+CXCR7+ LICs and suitable for immune scape (Figure 8 and Supplementary Figure S7C). Here, ACKR3 is linked to leukemia.