A pro-inflammatory and leukemia expansion (ILE) niche, where leukemic clones may proliferate and increase tumor burden in the context of an activating pro-inflammatory milieu, and an immune-suppressive and leukemia-initiating cell (SLIC) niche, endowed with immunoregulatory and suppressive properties and high transcription of CXCL10 and CXCL11. Here, CXCL11 is linked to leukemia.