EZH2 and glioblastoma: EZH2 inhibition in glioblastoma induced an increase in M1 markers (iNOS and TNF-α) and reduction in M2 markers (tumor growth factor-β1, -β2, and stabilin-1) in both murine microglia and human peripheral blood mononuclear cell-derived macrophages (77), which is indicative of the pro-M2 function of EZH2.