In hepatocellular carcinoma, cell cycle-related kinase (CCRK) enhanced IL-6 production via the abovementioned EHZ2/NF-κB signaling and induced increased accumulation of polymorphonuclear (PMN)-MDSCs (75), which suggests another mechanism by which EZH2 regulates MDSC generation. This evidence concerns the gene CDK20 and hepatocellular carcinoma.