IFNA1 and Autoimmunity: Several potential cross-links include the following: (1) SARS-CoV-2’s broad tissue/cell tropism with the emphasis of susceptibility in adipocytes (50–63); (2) intersecting immune dysregulation including IFN suppression, hyper-inflammation and thrombosis, T-cell atrophy, and autoimmune disorders; and (3) metabolic disruption of glucose and lipid biosynthesis.