In addition, the antibody response in MIS-C compared to adults with severe COVID-19 presents important differences, for example, a study showed that patients with MIS-C produced predominantly specific IgG antibodies (Abs) for the S protein but not for the N protein and in addition to a reduced neutralizing activity, while adult patients with COVID-19 presented Abs anti-S IgG, IgM and IgA, as well as Abs anti-N IgG, these results suggested that the immunological profile in MIS-C presents certain differential characteristics of COVID-19 in adults (62). This evidence concerns the gene CD40LG and COVID-19.