In insulinoma sample, ten oncogenes (BCL2, DDIT3, FGFR4, IRS2, KLF6, MAFB, MYCN, NTRK1, SOX2 and TLX1) were with either putative or reliable status of gain, and nine tumor suppressor genes (APC, ATM, ATR, BLM, FAS, HIF1A, LIFR, NBN and RB1) were with putative or reliable status of loss. This evidence concerns the gene KLF6 and pancreatic insulinoma.