PIEZO1 and dehydrated hereditary stomatocytosis: Gain-of-function mutations in PIEZO1 have been linked to Dehydrated Hereditary Stomatocytosis (DHSt), a rare red blood cell (RBC) disease also known as hereditary xerocytosis (Zarychanski et al., 2012; Albuisson et al., 2013; Andolfo et al., 2013).