Autophagy is impaired in the brains of patients and animal models with Alzheimer’s disease (Yang et al., 2011; Castellazzi et al., 2019; Pomilio et al., 2020), and this defect is associated with low Klotho expression and may be related to amyloid-β deposition (Zeng et al., 2019). Here, KL is linked to early-onset autosomal dominant Alzheimer disease.