KL and neoplasm: Thus, the dual role of Klotho in regulating autophagy, which can restore autophagy to beneficial levels, makes it a highly attractive target in anti-tumor therapy, not to mention that Klotho can also exert inhibitory effects on tumors through other biological activity, such as inhibition of Wnt and TGF-β1 signaling pathways (Rubinek and Wolf 2016).