Serum levels of Klotho are significantly decreased in patients with arterial stiffness and hypertension (Kitagawa et al., 2013), and Klotho deficiency has been shown to induce autophagy, which injures vasculature and causes arterial stiffening and hypertension (Chen et al., 2015; Chen and Sun 2019). The gene discussed is KL; the disease is hypertensive disorder.