In addition, SphK1−/− mice showed significantly reduced synovitis and joint pathology, and PF-543 and FTY-720 have also been shown to exert therapeutic effects against inflammation and angiogenesis in RA by regulating SphK1 and S1P/S1PRs signals, respectively (Bougault et al., 2017; Wang et al., 2021). This evidence concerns the gene MBTPS1 and rheumatoid arthritis.