Pharmacological experiments showed that CHJ01 exhibited anti-inflammatory effects similar to those of methotrexate in vitro and in vivo by reducing the swelling volume, arthritis score, spleen index and IL-1β, TNF-α, IL-6 levels in arthritis model rats, which contributed to the significant improvement of RA symptoms (Chen et al., 2021a). Here, IL1B is linked to arthritic joint disease.