SOD1 and amyotrophic lateral sclerosis: However, whether treatment with SFI could efficiently reduce OS damage and inhibit neurodegeneration in a well-established murine model of ALS—transgenic SOD1-G93A mice, which expresses large amounts of G93A, the mutant form of human SOD1, and develops adult-onset neurodegeneration of motor neurons and progressive motor deficits leading to paralysis (Gurney et al., 1994), and what the underlying mechanisms are mediating the action of SFI have not been explored.