PFKFB3 and hepatocellular carcinoma: Elevated glycolysis was observed in sorafenib-resistant HCC cells, and downregulating the key glycolytic enzymes 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (encoded by PFKFB3) or pyruvate kinase muscle isozyme M2 re-sensitizes HCC cells to sorafenib [31,36,37].