Interestingly, IGF2BP1 and HSP90AB1, which were identified to bind vRNA and regulate infection of SARS-CoV-2 in our study, were not in the list from the CRISPR screenings,59,60 suggesting that our interactome-informed focused screening can serve as a complementary assay to identify more functional host factors. The gene discussed is HSP90AB1; the disease is infection.