HSP90AB1 and infection: Given that our vRNA interactome datasets showed interactions between both ZIKV and EBOV vRNAs and heat shock proteins (e.g., HSP90, HSPA9, etc.)as well as cytoskeleton-related proteins (e.g., TUBA1C, TUBB), we also examined the antiviral effects of Cepharanthine and Trifluoperazine with infection assays against ZIKV in Huh7 cells (MR766, MOI 0.5) and against EBOVΔVP30-GFP (MOI 0.1) in Huh7.5.1-VP30 cells22 (the second and third row of Fig. 5a), respectively.