Consider that besides our demonstration that IGF2BP1 promotes translation of vRNA, our vRNA interactome and uvCLAP data may inspire following studies for the host factor HNRNPA2B1, a protein reported as an m6A reader responsible for microRNA processing and alternative splicing.61 Recently, mutations of m6A modification sites within the SARS-CoV-2 genome were linked to viral infection and transmission.62 In SARS-CoV-2 infection, HNRNPA2B1 may function as a regulator of vRNA through its recognition of m6A modifications. Here, IGF2BP1 is linked to viral infectious disease.