ROC curve analysis established 43.5% as the threshold distinguishing indolent from aggressive lymphoma (area under the curve = 0.847, P < 0.001): 81.4% of aggressive lymphomas had a LAT1 expression level > 43.5%, 89% of indolent lymphomas had a LAT1 expression level < 43.5%. The gene discussed is SLC7A5; the disease is lymphoma.