These comprise the top biological pathways enriched in mitochondrial iron-sulfur cluster biogenesis, metabolism of porphyrins, O2/CO2 exchange in erythrocytes, transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, MHC class II antigen presentation, Rhesus glycoproteins mediate ammonium transport, neddylation, creatine metabolism, potential therapeutics for SARS, oxidative stress induced cellular senescence, and amyloid fibre formation. This evidence concerns the gene SMAD4 and severe acute respiratory syndrome.